Asian Journal of Bio Science

N. Priya ¹, P. Venkatalakshmi ¹

Affiliations
1 Department of Biochemistry S.T.E.T Women’s College, Mannargudi ( T.N.), IN

Abstract

Solanum nigrum L., is a medicinal herb that has been used as nephroprotective agent in Chinese medicine. In this study, the protective effect of Solanum nigrum L., (SN) against gentamicin-induced nephrotoxicity in rats was evaluated. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/day for eight days. Effect of concurrent administration of fresh juice extract of Solanum nigrum at a dose of 100 mg/kg/day given by oral route was determined using serum creatinine, AST, ALT, blood urea, ALP, ACP, reduced glutathione, catalase, glutathione peroxidase and protein as indicators of kidney damage. The fresh juice extract of Solanum nigrum significantly protected rat kidneys from gentamicin-induced nephrotoxicity by normalizing the alterations in biochemical parameters. Hence, it can be concluded that the extract possesses significant nephroprotective activity.

Keywords

Gentamicin, Nephroprotection, Nephrotoxicity, Solanum nigrum.

Full Text

     

S. Sathya ¹, P. Venkatalakshmi ¹

Affiliations
1 Department of Biochemistry, S.T.E.T. Women’s College, Mannargudi (T.N.), IN

Abstract

Nephroprotective and antioxidant activities of Tephrosia purpurea have been evaluated against paracetamol and gentamicin induced renal damage in male albino rats. Paracetamol (200mg/kg) and gentamicin (40mg/kg) induced renal damage was well manifested by significant increase in the levels of ALT, AST, ALP, urea, creatinine, sodium in serum. On the other hand, the of levels potassium, protein, albumin, enzymatic and non enzymatic antioxidants were lowered. The oral administration of varying doses of ethanolic extract of Tephrosia purpurea (5,10 and 15 mg/kg) for the period of 7 days reversed these altered parameters to normal levels indicating the antioxidative and nephroprotective efficacy of Tephrosia purpurea L. against paracetamol and gentamicin induced renal injury.

Keywords

Acetaminophen, Carvedilol, Gentamicin and Tephrosia purpurea.

Full Text